ostermayer
Dan Ostermayer

https://www.pushhealth.com/practices/new-patients/2472/dostermayer

physician
metabolic health maximalist

📚
co-sleeping
https://a.co/d/0itAvPV
the simple world
https://a.co/d/5u4BdMU
📚

Public Key

npub1gc64tw6tp7q06ymkltnz374l4al9uvwdyaqasz4y6gjujf4u9plqz2uyek

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Profile Code

nprofile1qqsyvd24hd9slq8azdm04e3gl2l67lj7x8xjwswcp2jdyfwfy67zslspp4mhxue69uhkummn9ekx7mqpzamhxue69uhkv6tvw3jhytnwdaehgu3wwa5kuegpnfmhxue69uhkummn9ekx7mp0y5erqamnwvaz7tmwdaehgu3wd3skuep0y5erqffjxpshvct5v9ez2v3swaehxw309ahx7um5wgh8w6twv5hj2v3sy5erqctkv96xzu39xgc8wumn8ghj7ur4wfcxcetjv4kxz7fwvdhk6te9xgc8wumn8ghj7un9d3shjtnyv9kh2uewd9hj7ffjxpmhxue69uhhyetvv9ujuumwdae8gtnnda3kjctvqy2hwumn8ghj7erfw36x7tnsw43z7un9d3shjqgcwaehxw309ac8yetdd96k6tnswf5k6ctv9ehx2aqpzpmhxue69uhkummnw3ezuamfdejs24xnxk

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Last Notes

2026-02-03 00:06:20 UTC

almost all of the academic busy work that faculty deal with such as grant writing, paper writing, yearly performance review and peer review is made 1000 times easier with large language models and moonshot. K2 is a game changer.

2026-02-01 23:25:37 UTC

once you get on a glp-1 you will be on it for life unless you also make significant lifestyle modifications.
and when you get off it the weight will come back faster than the losses
https://www.bmj.com/content/392/bmj-2025-085304

2026-01-31 16:23:44 UTC

when you play a greyscale game, your mind activates to fill in the color. it is also easy to put it down because it i less "addictive" due to lower visual stimulation.
my kids love puzzle games on @nprofile…wsk5 and it is fun to watch them team up to solve them.

2026-01-31 10:55:56 UTC

embrace boredom.
sometimes it is exactly what your brain needs

2026-01-28 22:46:38 UTC

our need for sleep and the importance of long amounts of uninterrupted sleep may be driven by our mitochondria
During wakefulness, your neurons fire constantly, consuming enormous amounts of ATP. This drives the electron transport chain (ETC) at maximum capacity, which creates two critical problems: energy depletion and oxidation
1. Energy depletion: ATP gets hydrolyzed to ADP and AMP. The resulting low ATP/ADP ratio is a direct metabolic stress signal. Adenosine (formed from these breakdown products) accumulates and is a well-established sleep pressure molecule.
When we sleep neuronal activity decreases, allowing the electron transport chain to operate at lower capacity and reducing oxidation production and allow the reduction (opposite of oxidation) to catch up
the mitochondrial quality control mechanisms (mitophagy, biogenesis, fission/fusion dynamics) actively repair damage and replace dysfunctional mitochondria at a greater rate during sleep.
https://www.science.org/content/blog-post/it-all-comes-down-mitochondria

2026-01-27 13:30:53 UTC

it is widely accepted in veterinary medicine that many canine skin disorders are as a result of zinc deficiency and poor gut health. after treating any topic fungal or bacterial infections, most vets will suggest a probiotic supplemented with minerals to maintain high quality fur grown and skin health. very rarely do we see this offered in human medicine but it in fact clears up many skin issues though to be "autoimmune"
https://link.springer.com/article/10.1007/s40257-019-00484-0
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0625.2009.00932.x

2026-01-27 13:11:32 UTC

the basis of modern virology
https://blossom.primal.net/f13f364a8faf2df8e74a51b8fed2a5860c1b2d7049f26135dabb4de9af1fe504.mp4

2026-01-27 01:51:47 UTC

in medicine it is always enlightening to find natural controls. the Amish population serve as a human control --- but from a genetic standpoint, chimps serve as a control as well.
chimps in captivity have an approximate 2% cancer incidence yet share 99% similar genetics as humans. either that 1% genetic difference accounts for all of the increased malignancies in humans or humans have done something to themselves that create all of the malignancies that plague our modern health.
many will say that we get cancers because we live longer but captive chimpanzees live twice as long (15+ years more) than wild chimps so their lack of cancer is eye opening.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1382208/
https://blossom.primal.net/b779eff58d938cf85786a5d5151ae9edb3b6e98883343fb7eef790bd45a50ec1.jpg

2026-01-25 13:12:11 UTC

People feel invigorated after an ice bath because cold receptors in your skin trigger sympathetic nervous system activation. Plasma norepinephrine and dopamine spike within seconds since your physiologic response is to "get out as fast as possible"
Then your pituitary gland pumps out beta-endorphins to bind opioid receptors to counteract the pain of the cold exposure (just like a runners high)
Vasoconstriction shunts blood to your core. When you exit, peripheral vasodilation creates a surge of oxygenated blood to your muscles and brain.
Your cognitive override of all these systems trying to get you out of the bath is fed by a later dopamine reward and your normal warm environment then feels like a luxury.
https://blossom.primal.net/20bf48c1cf820b94b5ef4dde718a764bdfb79584131025ffc5852317714931a1.jpg

2026-01-24 13:02:00 UTC

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a healthcare practice can stop serving patients if they also don't keep their end of the bargain....check their yearly fasting insulin and you a good screening for patients who you want to serve. when you stop serving them they don't pay you but also don't get access to you.

2026-01-24 13:00:21 UTC

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a healthcare practice and stop serving patients if they also don't keep their end of the bargain....check their yearly fasting insulin and you a good screening for patients who you want to serve

2026-01-23 07:16:39 UTC

the concept of the "6 month dental health check and cleaning" is largely a construct of dental insurance coverage. it was created as part of a pepsodent tooth paste advertisement in the 1950s and then solidified by dental insurance.
when you sign up for a dental plan you are essentially prepaying for the teeth "cleaning". this is why if you are self pay they rarely ever call you to get your teeth cleaning since they know you won't want to pay for it if you haven't already prepaid via your employer plan.
there has never been any scientific backing to visiting a dentist twice a year. is it a good idea...maybe but also is like visiting a mechanic when you don't have an issue...
https://blossom.primal.net/21251825deffeae665efd265d8b48c2180981c27b2b43f2360a1c901e3766cee.jpg

2026-01-22 13:46:58 UTC

this viral control study is the best modern one that I have read. They purposely inoculated people with H3N2 and then compared the transmission in masks https://blossom.primal.net/8f72773b1f2b8d80ccda689979ed5c3f62e1e47550e94950ce2e1e9e49833f72.png vs no mask and unfortunately only one transmission event occurred. It was so hard to get people sick with H3N2 even when being quaranteened in the same room that they concluded that it must be the ventilation rather than then possibility that something might be wrong with the theory of contagion.
https://blossom.primal.net/4cd75b49a989faf0a789d7d1de920b555d420792432a2ed4b06f4e2439b0a293.jpg
https://files.ostermayer.co/contagion/ppat.1008704.pdf https://blossom.primal.net/ae2bddb13c3330e4cbd61607c5b652bde593521a93e83d221d0dcd1f9b0545f0.png

2026-01-21 12:15:35 UTC

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yeah i did and it seems pretty standard in terms of hippa protection. unfortunately with almost any hospital or online health system there are business associate agreements where they can do research and data analysis on large chunks of anonymized data. even your local hospital does that

2026-01-21 12:14:54 UTC

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2026-01-21 12:07:23 UTC

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really?

2026-01-21 11:03:59 UTC

not sure how function health gets their labs down so cheap but it is better for most people to get all their labs from them and then just take the results to their doctor for review if they have questions
https://my.functionhealth.com/signup?code=DOSTERMAYER10&_saasquatch=DOSTERMAYER10&d=FHREF25

2026-01-18 03:46:52 UTC

i have helped run a wiki for emergency medicine since i was a resident and of all the things that I have done in medicine, bringing open access medical knowledge to clinicians around the world has brought me the greatest joy. No paywalls. No fees. Available at the bedside globally.
at wikem.org we have created the greatest open medical textbook for clinicians.
we are now using LLMs to translate every page into spanish at a speed i could have never imagined

2026-01-17 17:51:36 UTC

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https://medium.com/@ashwinnaik/paying-the-doctors-as-long-as-they-keep-you-healthy-b694d07a9db
https://blossom.primal.net/57dab7f7e626f4d7f308e418d04c24f4106c72b653a58692994cc899e4c86f32.jpg
#nevent1q…xxnf

2026-01-17 17:38:54 UTC

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💯
#nevent1q…jc5q

2026-01-17 17:00:03 UTC

right now healthcare practices make money when people get sick, imagine a healthcare practice that you pay for that keeps you healthy and sick visits are free.
the physician has a financial interest to keep your healthy since the less sick you are the less time they need to spend with you in the office and the less time the patient has to take time off of work to see the doctor.

2026-01-17 12:09:20 UTC

https://futurism.com/artificial-intelligence/amazon-data-center-oregon
ground water filtration is a time dependent process and data centers can very easily overwhelm that process
high localized water usage essentially reverses the normal filtration process taking place with the soil. data centers aren't adding nitrates but are "hyper concentrating them" by using the water faster than normal ground filtration can support
https://blossom.primal.net/8f0aaa9dc9affbfa5ca4ac3d0f60ae49c5ed42a7f79e61ae585354bc8976ac1c.jpg

2026-01-16 13:21:04 UTC

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refined sugars too and for some over eating in caloric excesses. in theory you could overeat saturated fats as well but we certainly eat less satieting (aka less energy) dense calories

2026-01-14 15:46:23 UTC

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https://pubmed.ncbi.nlm.nih.gov/17456621/
#nevent1q…jf9k

2026-01-14 15:10:04 UTC

perhaps we should be prescribing colostrum rather than the influenza vaccine
https://journals.sagepub.com/doi/epdf/10.1177/1076029606295957
https://blossom.primal.net/501689e9ecdd0dce5a17847619af7ced054ebd383d883da8571b79dcd450156d.jpg
https://blossom.primal.net/069b1d6f1fb396208725ef9c7a1b7b201a1d5d128e42e527c94fa1681464fea9.jpg

2026-01-14 00:44:11 UTC

here is an example of how a pharmaceutical company can create a trial to make a drug ( in this case xofluza) look good while being essentially useless. many urgent cares are giving flu patients this med to "treat their flu".
first they create a primary subjective outcome (time to symptom improvement)
that endpoint showed "29 hr time" benefit for symptom improvement but when looking at return to pre-illness health it showed no significant difference compared to placebo (126.4h vs 149.8h, p=0.46)
they will choose healthy patients and exclude those who may suffer adverse effects - and they exclude hospitalized patients who may not even show a benefit
they will also focus on surrogate outcomes such as viral load irrespective of symptoms correlated to viral load
then they will bury a red flag deep in the paper where 9.7% of baloxavir-treated patients with H3N2 developed resistance mutations during treatment.
then they will perform a modified intention-to-treat (mITT) analysis and exclude 2.6% of patients from non-GCP-compliant site to potentially minimize data on patients with side effects that prevent their trial participation
all of this creates a publication that can headline as a great drug but really fails to improve patient health compared to placebo.
https://files.ostermayer.co/ison2020.pdf

2026-01-11 13:32:26 UTC

non-alcoholic fatty liver disease is a global problem. humans are turning into foie gras
low carbohydrate high protein diets are the best way when paired with intermittent fasting to purge the liver of excessive fat deposits.
then people can resume non grain carbohydrates once back to a normal body weight.
https://ecodanusa.pt/wp-content/uploads/2024/05/Riazi_NAFLD-prevalence-worldwide-2023.pdf
https://blossom.primal.net/9291581c827870ea6786da00b8fd6e228311d197240b6267db4a09deac578fb1.jpg
https://blossom.primal.net/2d1837d2360cd409b20f35eea1e5ef5d56a90adb88f10e13eb01c2fa27266f22.jpg

2026-01-11 12:29:14 UTC

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nature is amazing.
#nevent1q…swd9

2026-01-10 22:07:46 UTC

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still most proud of this book. it was my "covid" moment
#nevent1q…qfek

2026-01-10 22:06:17 UTC

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💯
#nevent1q…pjzq

2026-01-08 12:45:17 UTC

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https://blossom.primal.net/89d620e23499b5557631a29348c9f9bd9475ed5ad1574f341b109e385ebc22ec.png
https://blossom.primal.net/06240b9c6ae2f0aab64fa879c9b4a110c6cb37b151734afd8a74ebd0baa41a11.png
#nevent1q…hsgc

2026-01-08 12:38:04 UTC

because type 2 diabetes is a function of mitochondrial dysfunction even though we talk about it as "insulin resistance" it makes physiologic sense that creatine supplementation improves glucose tolerance and fasting glucose levels in diabetics
https://pmc.ncbi.nlm.nih.gov/articles/PMC7915263/

2026-01-08 00:31:26 UTC

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http://realfood.gov/
#nevent1q…8ctp

2026-01-07 23:46:40 UTC

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tons of typos in this. i rewrote here:
https://primal.net/e/nevent1qqsz8e0grh8s0lt3wv08y7xjl5munkg9zujw7t6ay5jplhxuzkxahyscj7gek

2026-01-07 23:05:29 UTC

not that you really need a food pyramid but here is the new one
https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health
https://blossom.primal.net/66603610fa5c1d58341f0c3b40a89981f4a8793120af946c0c721ab022e4fca6.png

2026-01-07 22:51:37 UTC

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i walked through the viral control group findings here with their project manager
https://primal.net/e/nevent1qqs92tj3sf6hz2jen8fgh9rekmluyfzae8pqfmz7dv44ky2qtjyngvqhhq8ym

2026-01-07 22:49:54 UTC

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my review of this non peer reviewed study
https://www.medrxiv.org/content/10.1101/2025.01.30.25321421v4
This prospective cohort study evaluates the effectiveness of the 2024-2025 influenza vaccine among 53,402 employees of the Cleveland Clinic Health System. Using a time-dependent covariate Cox proportional hazards model, the authors report that they were unable to identify a protective effect of the vaccine.
There is a strong likelihood that the results are driven by unmeasured confounding, specifically differential healthcare-seeking behavior and detection bias.
Ther defense against this bias is not great. The authors admit in the results are driven by vaccinated individuals being significantly more likely to undergo PCR testing than unvaccinated individuals.
They argue that because the test positivity rate was similar between groups (figure 2), the higher case count involves true infection rather than PCR test seeking behavior.
If the vaccine has low or null effectiveness and the vaccinated population is tested at a rate 1.5x or 2x higher than the unvaccinated population, the observed incidence rate will be higher in the vaccinated group simply due to increased case ascertainment.
A similar test positivity rate across groups, combined with higher testing volume in one group, means we would expect to find more cases in the high-testing group.
The study is really just measuring the "incidence of detected influenza," which appears to be a function of testing and they were unable to adjust for "propensity to seek care."
It is not possible to find an associated increased case of influenza with vaccination but there is no doubt from this data set that the influenza vaccine had little to zero protective effects in terms of getting the disease --- and therefore raises the question are potential adverse effects worth the injection if it doesn't protect against the disease?

2026-01-07 22:45:19 UTC

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hey chris. i admit i am not sure here and am trying hard to understand if virology is a appropriate representation of reality
here is the collection of contagion studies i have found from old old publications
https://files.ostermayer.co/contagionstudies.zip

2026-01-07 17:31:32 UTC

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https://primal.net/e/nevent1qqsdns70jgz7glgc5pepwf3m3qqt8wdqq0gn5xsfvut0vshg8ap7swgtyrnwz

2026-01-07 17:00:26 UTC

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https://primal.net/e/nevent1qqsdns70jgz7glgc5pepwf3m3qqt8wdqq0gn5xsfvut0vshg8ap7swgtyrnwz

2026-01-07 16:16:07 UTC

a common refrain of preprint papers is that they "haven't undergone peer review"
https://www.medrxiv.org/content/10.1101/2025.01.30.25321421v4
this is a reminder to anyone who can read and understand scientific publications "WE ARE THE PEER REVIEW"
here is my review of this paper:
This prospective cohort study evaluates the effectiveness of the 2024-2025 influenza vaccine among 53,402 employees of the Cleveland Clinic Health System. Using a time-dependent covariate Cox proportional hazards model, the authors report that they were unable to identify a protective effect of the vaccine.
There is a strong likelihood that the results are driven by unmeasured residual confounding, specifically differential healthcare-seeking behavior and detection bias.
Ther defense against this bias (Figure 2 analysis) is not great. The authors admit in the results (are driven by vaccinated individuals being significantly more likely to undergo PCR testing than unvaccinated individuals.
They argue that because the test positivity rate was similar between groups (Figure 2), the higher case count involves true infection rather than PCR test seeking behavior.
If the vaccine has low or null effectiveness and the vaccinated population is tested at a rate 1.5x or 2x higher than the unvaccinated population, the observed incidence rate will be higher in the vaccinated group simply due to increased case ascertainment. A similar test positivity rate across groups, combined with higher testing volume in one group, means we would expect to find more cases in the high-testing group.
The study is really just measuring the "incidence of detected influenza," which appears to be a function of testing and they were unable to adjust for "propensity to seek care."
It is not possible to associated increased cases of influenza with vaccination but there is no doubt from this data set that the influenza vaccine had little to zero protective effects. and therefore raises the requesting of are potential adverse effects worth it.

2026-01-07 15:01:24 UTC

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it is so hard to know. the literature is so poisoned with publication bias that negative studies are never published.
the only throng that will unravel this mess is mass release of anonymous patient level data for open analysis rather than selective publications

2026-01-07 14:43:27 UTC

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correct. but it did fail to find evidence of vaccine protection as did a prior NHS study

2026-01-07 13:44:59 UTC

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correct. my hypothesis is that we shed cellular debris and it is possible for our cellular debris to make others sick but mostly our internal metabolism determines whether we get sick not the "pathogens"around us

2026-01-07 02:31:09 UTC

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one of the best influenza vaccination population studies originated from the UK NHS in 2020 https://blossom.primal.net/f54ad639d538592b2c70a372b93906a71debfb9e060be9d96816f71b9c37be3d.png
"Vaccination rates rose significantly at 65, but there was no corresponding statistically significant reduction in influenza/pneumonia hospitalizations (estimated effect: –5.8%, 95% CI –25.3% to 12.9%) or all-cause mortality"
https://blossom.primal.net/11b8c4ffeb038af6380d26eb9c441f3f4d5369a90bcb2f34be112b2a5d83e557.pdf
#nevent1q…vyac

2026-01-07 01:56:11 UTC

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i think i know why https://primal.net/e/nevent1qqs92tj3sf6hz2jen8fgh9rekmluyfzae8pqfmz7dv44ky2qtjyngvqhhq8ym

2026-01-07 00:30:01 UTC

from last year's flu vaccination season
https://www.medrxiv.org/content/10.1101/2025.01.30.25321421v4
"Among 53402 working-aged Cleveland Clinic employees, we were unable to find a protective influence of influenza vaccination during the 2024-2025 respiratory viral season and found a significantly higher risk of influenza with vaccination when influenza activity was high."
https://blossom.primal.net/2214c6ae13b8823bf0982a7c625373d50c1d7fd41a163a27e035620a47225589.jpg

2026-01-03 17:33:35 UTC

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👇
#nevent1q…g4vs

2026-01-02 16:53:32 UTC

i exclusively wear altra running and vivo barefoot shoes
wide toe box always
https://blossom.primal.net/8a362e4b30aba9cfce2cb364620bfb9087a0b1eb620f3e0b745bbcba5eefddab.jpg

2025-12-31 21:57:52 UTC

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💯
#nevent1q…w6pt

2025-12-31 21:30:57 UTC

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i tend to agree. but when mitochondrial dysfunction emerges and glucose dysfunction is seen, the ldl does get used pathogenically

2025-12-31 21:23:23 UTC

pretty good summary of all of the great knowledge that emerged (and has been been forgotten) from the Swedish-Amoris study
https://ecancer.org/en/journal/article/555-metabolic-serum-biomarkers-for-the-prediction-of-cancer-a-follow-up-of-the-studies-conducted-in-the-swedish-amoris-study/pdf
most summary articles still interpret the findings from the lens of lipids and glucose synergistically drive risk risk rather than glucose drives lipid pathology and also drives cardiovascular and cancer risk

2025-12-31 21:13:14 UTC

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https://blossom.primal.net/65b8f2ecd21f67c2be8217c423edd198f5c096c9b1d6e8a0ccb1b1c6bf1988b2.jpg
#nevent1q…7x3j

2025-12-31 21:12:44 UTC

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https://pubmed.ncbi.nlm.nih.gov/30421156/
https://pubmed.ncbi.nlm.nih.gov/21630265/
https://blossom.primal.net/4df866c3b59cae9f2a065c9a632d0fdcc3e4a2b7ed0c7bec1f338f708ad9d81e.jpg
#nevent1q…75fs

2025-12-31 21:05:03 UTC

the swedish amoris (Apolipoprotein-related MOrtality RISk)
https://ki.se/imm/forskning-vid-imm/enheter-vid-imm/enheten-for-epidemiologi/how-it-all-started
https://www.researchgate.net/publication/313385633_The_AMORIS_cohort
https://pubmed.ncbi.nlm.nih.gov/21630265/
this landmark study showed how elevated blood glucose levels are driving the pathology that is associated with cholesterol. when humans have normal blood glucose their body thrives off of cholesterol and when they have diabetes, cholesterol becomes fuel for their internal derangements
https://blossom.primal.net/4df866c3b59cae9f2a065c9a632d0fdcc3e4a2b7ed0c7bec1f338f708ad9d81e.jpg

2025-12-31 20:27:12 UTC

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strengthen that lower back with squats and kettle bell swings this year.
strengthen those abs with really high box jumps
#nevent1q…3z4y

2025-12-31 20:24:24 UTC

wishing everyone on this protocol a happy 2026. has been wonderful fun creating posts for you all
https://blossom.primal.net/3f119e1728492831434d004ff18f2737ffccd54f9276bc0e874b48ccd9dcaa84.png

2025-12-31 05:15:53 UTC

it is great to see research focusing on the metabolic cause of alzheimer's. NAD+ issues relate to the mitochondria dysfunction that occurs after years of metabolic dysfunction.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
i think for now the best everyone can do is get their fasting insulin down below 7 and take creatine daily
https://pmc.ncbi.nlm.nih.gov/articles/PMC10594571/
https://blossom.primal.net/ef4542595f856be88685ab8c7eb42b9d38e04782d0227fb425f51b858b6ee325.jpg

2025-12-29 16:34:46 UTC

if you do take a vitamin d supplement always consume it with K2 and best to just get it from sunlight and liver (has natural k2 to vitamin d3 ratio)
otherwise taking vitamin d3 in isolation overwhelms you body with sequestered calcium

2025-12-27 20:04:17 UTC

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this is at the core of why so many of us remember the 90s being wonderful

2025-12-27 19:06:51 UTC

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unless you can "fix a disease" so they can be productive again
#nevent1q…zfv0

2025-12-27 19:05:28 UTC

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healthcare is an unproductive industry
#nevent1q…c595

2025-12-27 18:20:25 UTC

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i hear you. wisdom are the first principle truths not the politically and narrative driven teaches. many points of wisdom in ancient writings

2025-12-27 14:42:44 UTC

the animal based nutritional research foundation is doing wonderful research
https://donorbox.org/give-today-transform-tomorrow-fueling-a-radical-2026-864420
this is @nprofile…uyxm organization and i owe him a lot of gratitude for his original carnivore book that opened my eyes to the ancestral animal based diet we forgot in the modern age. before that i floundered with plant based diets and all the standard teachings of medical school vilifying cholesterol and pushing vitamin supplements.

2025-12-27 14:06:15 UTC

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we live in a biblical wisdom dark ages of ethics and biology

2025-12-27 14:05:34 UTC

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yeah. all animals have linoleic acid just low percentage that seems biologically safe. we see this in our pigs over time. pasture pigs have low percentage but soy fed pigs huge percentage

2025-12-27 14:04:20 UTC

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in other nuance. the cooking of pufa increase the oxidation chances which lead to many of the harms of the cooked pufa vs the "raw" oxidized pufa. then though no pufa is shelf stable given light and oxygen exposure

2025-12-27 12:54:25 UTC

vitamin D has never been isolated from humans in a form distinct from vitamin D₃ (cholecalciferol). In humans, only vitamin D₃ has been identified This compound is produced in the skin when 7‑dehydrocholesterol is irradiated by UV‑B light.
The term "vitamin D₁" was initially used but was later discovered to be an artifact—a mixture of vitamin D₂ and another compound
The first pure vitamin D to be isolated and identified was vitamin D₂ (ergocalciferol), but this was from plant/fungal sources (like irradiated yeast), not from humans
https://pmc.ncbi.nlm.nih.gov/articles/PMC9066576/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3899558/

2025-12-27 12:10:39 UTC

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the fat in an egg is part of its structure compared to canola oil in a recipe but the daily percentage does matter as you store the pufa content in your adipose tissues.
we have native pufa in our body and that is good, it is just that our percentage has increased substantially

2025-12-26 13:22:50 UTC

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long time ago. just giving some recent recommendations

2025-12-25 17:27:59 UTC

great sci fi books i've read over the last few years:
Delta-V by Daniel Suarez
Kill Decision by Daniel Suarez
Daemon by Daniel Suarez
Freedom TM by Daniel Suarez
Nexus by Ramez Naam
Silo Series by Hugh Howey
Sand Chronicles by Hugh Howey
Project Hail Mary, by Andy Weir
All Systems Red, by Martha Wells
Recursion, by Blake Crouch
The Long Way to a Small, Angry Planet, by Becky Chamber
Red Rising, by Pierce Brown
Exhalation, by Ted Chiang
We Are Legion, by Dennis E. Taylor
Children of Time, by Adrian Tchaikovsky

2025-12-24 15:23:08 UTC

https://pmc.ncbi.nlm.nih.gov/articles/PMC4392553/
glyphosate, the world's most widely used herbicide, inhibits CYP enzymes -- the very enzymes we need to synthesize vitamin D from sunlight and cholesterol

2025-12-24 13:20:56 UTC

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definitely correct!
k2 regulates calcium and magnesium zinc, boron all of which need to be in appropriate ratios
if you added k2 to vitamin d rat poison it wouldn't kill the rat, the rat would get healthier. vitamin d depletes k2 which then leads to calcium overload.
https://www.mdpi.com/2072-6643/13/2/691
#nevent1q…k8p4
#nevent1q…2pyh

2025-12-24 13:06:05 UTC

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yes of course cold exposure and activity in the cold my improve the immune system https://apps.dtic.mil/sti/pdfs/ADA411099.pdf

2025-12-24 13:01:41 UTC

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when you investigate vitamin d it gets even stranger.
i have never been able to ever find the molecular structure of vitamin d that is isolated from humans, only d2 from UV irradiated yeast or d3 synthesized from lanolin
the original "discovery" in 1920 is also in yeast as a pharmaceutical to treat rickets
#nevent1q…r643

2025-12-24 01:43:38 UTC

some hidden truths about vitamin d3 supplements (Cholecalciferol)
(it is an active ingredient in rat poison)
The hormone form of D signals your intestines to preferentially absorb calcium over magnesium.
Magnesium is anti-inflammatory; calcium is inflammatory
D3 from wool which is coated in lanolin (sebaceous gland secretions)gets washed with industrial detergents. The extracted lanolin then undergoes a "dehydrobromination reaction" using either 2,4,6-trimethylpyridine (derived from coal tar) or a cocktail of sodium hydroxide, potassium hydroxide, N-Bromosuccinimide, and chloroform.
D3 toxicity typically requires doses above 10,000 IU daily for months
when you get your "vitamin D" level checked the lab is testing for the presence of synthetic markers – specifically, they're measuring 25-hydroxyvitamin D, which is what your liver creates from cholecalciferol.
The Inuit, living in darkness for months, eating a diet of seal and whale – no rickets, no vitamin D deficiency. Traditional cultures worldwide, no access to supplements, no fortified foods, yet no epidemic of bone diseases.

2025-12-23 19:25:21 UTC

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haha! it doesn't!! yet it still gets the flu randomly. so it begs the question what is causing it there if these qualities of "seasonal transmission" are absent all year long.
we attribute the flu to the seasonal events that make transmission more likely yet we see the flu like symptoms in places where there are not augmented transmission qualities.
perhaps as you suggest it is from something not related to seasonality and more to do with human deficiency

2025-12-23 19:22:24 UTC

i really like this flu study.
what causes the flu in equator level counties if it isn't from the cold, isn't from being indoors on a seasonal basis and isn't from changes in relative humidity
"Through this, we show that influenza in Vietnam does not show consistent timings, making preparedness efforts such as vaccination campaigns difficult to design."
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011317

2025-12-23 19:13:05 UTC

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why does it not persist in low humidity cold climates during summer months such as northern canada?
why is it seasonal everywhere despite low humidity cold climates being present in some areas always that would create "non seasonal" events
why do we see flu season at the equator where there is really no seasonal climate variations?

2025-12-23 19:08:00 UTC

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where does it go in the summer?

2025-12-23 19:07:42 UTC

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how does it travel in winter in places with high humidity like florida and texas?

2025-12-23 18:44:38 UTC

this is the explanation for why the flu is seasonal:
1. Viral Stability in Cold, Dry Air:
Influenza viruses survive better and remain in the air longer when the air is cold and dry. Low absolute humidity (the total amount of water vapor in the air, which is lower in winter even when relative humidity is high) allows the tiny respiratory droplets that carry the virus to stay suspended for longer periods and travel farther.
2. Host Immune Response: Cold, dry winter air can also impair our innate immune defenses. The mucociliary clearance system, which is the layer of mucus and tiny hairs (cilia) in our respiratory tract that traps and clears out pathogens, works less efficiently in these conditions
3. Human Behavior: During colder months, people spend significantly more time indoors in closer proximity to one another. This increased crowding in homes, schools, and offices facilitates easier transmission of the virus through respiratory droplets and aerosols.
does this sound logically coherent to you?

2025-12-23 13:58:39 UTC

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and taking this one step further. there should be no diseases that severely disable adults raising children since humans have such a prolonged "childhood" compared to other species.
the adults that have disabling diseases would have died off and failed to raise capable children that would never have created thriving tribes of other humans
#nevent1q…9jqz

2025-12-23 13:51:42 UTC

there are no conditions that would survive from an evolutionary perspective that severely disabled young people before having children.
you should not be hearing about young adults and teenagers having strokes and heart attacks.

2025-12-21 17:38:44 UTC

a common statement in infectious disease: "if something is highly infectious and not lethal it spreads far but highly lethal and infectious won't spread"
ask yourself: if something kills a host very quickly and people learn to avoid that sick person so they don't immediately die, how does the "virus" continue to exist?

2025-12-21 17:34:24 UTC

the best peer review is scientific experiment replication. if different groups do the same experiment over and over and get the same result there is no need for peer review.
replication is the only valid peer review.

2025-12-21 17:31:09 UTC

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a recurrent theme is that we need to build a better peer review system. this is misguided. all you need to do with any scientific publication is find a place to host your data and publish everything.
nostr doesn't fix this.
bitcoin doesn't fix this.
the only thing that fixes this is scientists learning how to use multiple CDNs and torrents
if you did something that is logically excellent your data speaks for itself. just release the data.
#nevent1q…2kck

2025-12-20 21:45:36 UTC

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and the hardest part is correcting wrong ideas.
#nevent1q…cykm

2025-12-20 17:39:59 UTC

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https://www.arizton.com/market-reports/us-continuing-education-market
#nevent1q…8f7u

2025-12-20 17:39:07 UTC

the multi billion dollar counting education market is in for a rude awakening with LLMs.
https://finance.yahoo.com/news/u-continuing-education-ce-market-102900804.html

2025-12-19 13:51:01 UTC

the only thing that can be tested in a randomized double blind placebo controlled trial is a pharmaceutical intervention.
everything else, even if randomized gets labeled as lesser quality evidence. (can't test organ meat ingestion and exercise this way)
this is why evidence based medicine has been co-opted by drug based interventions. those molecules get the highest stamp of evidence based guidelines

2025-12-19 13:02:08 UTC

the only thing that can be tested in a randomized double placebo controlled blind trial is a pharmaceutical intervention.
everything else, even if randomized gets labeled as lesser quality evidence. (can't test organ meat ingestion and exercise this way)
this is why evidence based medicine has been co-opted by drug based interventions. those molecules get the highest stamp of evidence based guidelines

2025-12-18 21:31:32 UTC

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yes, and the intentional side effect of not tasting great is that when they add in sugar, it makes you want to eat more which means buy more which means more profits

2025-12-18 20:24:21 UTC

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a common mainstream critique will be "they didn't get dementia or a stroke because they died of a heart attack first from all the saturated fat"
except, that didn't happen... https://blossom.primal.net/3bfb6ff157e92883ea227756a993c08823b710c1a9078851b0f08e4b3bf65a82.png
https://blossom.primal.net/86be27894d25805a079d0c69fb514a619a01aec6ecf4e7265f07de9f250c1af0.png
#nevent1q…7ztp https://blossom.primal.net/544e4d505fee0dc5928d0073d6b1d43e69e25fbc0fd01aba2893ed5c191e1bd1.png https://blossom.primal.net/aae6004feb7c3b1fe37a240a8b701fe7c6b79fa860d471d76c612d3e5d39a120.png https://blossom.primal.net/9d550a74a59d4bef448280d08933d9e053a1dff3ce5dff09d41772de6f0e36fc.png
https://files.ostermayer.co/nutrition/du-et-al-2025-highlowfat.pdf

2025-12-18 15:52:05 UTC

file this under the obvious for must of here but a shocker for the mainstream. high saturated fat creates the cholesterol building blocks for a healthy brain
"Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. "
https://www.neurology.org/doi/10.1212/WNL.0000000000214343

2025-12-17 18:19:00 UTC

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https://blossom.primal.net/0ed269b332b6bc5c5f934fae389cdfd628dad57c7c461041ce636657ce607562.jpg
#nevent1q…ukeh

2025-12-17 18:13:16 UTC

mental health flows from physical health
physical health flows from mental health.
"stop fixing yourself" is a great book by anthony de mello

2025-12-17 00:09:39 UTC

vitamin A and E deficiency in many people with acne
liver, grass fed butter and egg yolks are great sources
https://www.researchgate.net/profile/Khalid-Abdul-Razzak/publication/243464504_Does_the_plasma_level_of_vitamins_A_and_E_affect_acne_condition/links/5e8af7664585150839c40298/Does-the-plasma-level-of-vitamins-A-and-E-affect-acne-condition.pdf

2025-12-15 14:11:56 UTC

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yeah i get it

2025-12-15 13:56:25 UTC

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best to just present the evidence and don't try and convince